Mid-Infrared Photonics in Silicon

The mid-infrared wavelength region (2-20 µm) is of great utility for a number of applications, including chemical bond spectroscopy, trace gas sensing, and medical diagnostics. Despite this wealth of applications, the on-chip mid-IR photonics platform needed to access them is relatively undeveloped. Silicon is an attractive material of choice for the mid-IR, as it exhibits low loss through much of the mid-IR. Using silicon allows us to take advantage of well-developed fabrication techniques and CMOS compatibility, making the realization of on-chip integrated mid-IR devices more realistic. The mid-IR wavelengths also afford the opportunity to exploit Si's high third-order optical nonlinearity for nonlinear frequency generation applications. In this work, we present a Si-based platform for mid-IR photonics, with a special focus on micro-resonators for strong on-chip light confinement in the 4-5 μm range. Additionally, we develop experimental optical characterization techniques to overcome the inherent difficulties of working in this wavelength regime. First, we demonstrate the design, fabrication, and characterization of photonic crystal cavities in a silicon membrane platform, operational at 4.4 μm (Chapter 2). By transferring the technique known as resonant scattering to the mid-IR, we measure quality (Q) factors of up to 13,600 in these photonic crystal cavities. We also develop a technique known as scanning resonant scattering microscopy to image our cavity modes and optimize alignment to our devices. Next, we demonstrate the electro-optic tuning of these mid-IR Si photonic crystal cavities using gated graphene (Chapter 3). We demonstrate a tuning of about 4 nm, and demonstrate the principle of on-chip mid-IR modulation using these devices. We then investigate the phenomenon of optical bistability seen in our photonic crystal cavities (Chapter 4). We discover that our bistability is thermal in origin and use post-processing techniques to mitigate bistability and increase Q-factors. We then demonstrate the design, fabrication, and characterization grating-coupled ring resonators in a silicon-on-sapphire (SOS) platform at 4.4 μm, achieving intrinsic Q-factors as high as 278,000 in these devices (Chapter 5). Finally, we provide a quantitative analysis of the potential of our SOS devices for nonlinear frequency generation and describe ongoing experiments in this regard (Chapter 6).Engineering and Applied Science

Registration of Airborne Infrared Images using Platform Attitude Information

In current warfare scenario stealth and passive threat detection capabilities are considered as prime requirements to accomplish desired mission by the fighter aircrafts. To improve the stealth of an aircraft, the trend is towards detecting threats with the help of passive sensors (Electro Optic or Infrared). Current situation caters for systems like Infra-red Search and Track (IRST) and Passive Missile Warning Systems (PMWS). IRST system is a passive target detection system, used for detecting aerial & ground targets. PMWS is a threat detection system used for detecting missiles approaching towards aircraft. Both of these systems detect targets of interest by processing IR images acquired in mid-IR region. The prime challenge in IRST system or PMWS is detecting a moving target of size typically 1~2 pixels in acquired image sequences. The temporal change caused by moving target in consecutive frames can be considered as one important factor to detect them. The temporal change caused by moving target is identified through absolute frame differencing of successive frames. This principle has limitation in application to IRST & PMWS as the imaging sensor with the aircraft is moving. This motion also imparts temporal change in the acquired images. In this paper authors are proposing a method for removing the temporal change caused by the platform motion in two consequently acquired frames using registration process.  The proposed method uses the platform attitude information at frame sampling times. Authors have analyzed the sensitivity of registration process to noisy platform attitude information.Defence Science Journal, 2014, 64(2), pp. 130-135. DOI: http://dx.doi.org/10.14429/dsj.64.546

The subcellular distribution of myeloid-related protein 8 (MRP8) and MRP14 in human neutrophils

BACKGROUND: Myeloid-related protein 8 (MRP8) and MRP14 are S100 family calcium binding proteins that form a heterodimer known as calprotectin or MRP8/14 that is present in the cytosol of neutrophils and monocytes. MRP8/14 becomes associated with endothelium at sites of monocyte and neutrophil adhesion and transmigration and induces a thrombogenic and inflammatory response by increasing the endothelial transcription of proinflamatory chemokines and adhesion molecules. The distribution of MRP8/MRP14 among neutrophil granules and plasma membranes is unclear and was investigated to better understand the role of this molecule in acute inflammation. STUDY DESIGN: Three monoclonal antibodies specific for MRP8 and MRP14 were characterized and used in immunoblotting assays of neutrophil whole cell extracts, and isolated plasma membranes, primary granules, secondary granules and cytosol. RESULTS: MRP8 and MRP14 were detected in neutrophil cytosol, plasma membrane, primary granule and secondary granule fractions. MRP8/14 demonstrated a calcium-dependent adherence to plasma membranes and primary granules and could be removed by washing with EGTA in a high ionic strength buffer. In contrast, MRP8/14 was found within the contents of the secondary granules. Activated neutrophils released secondary granules and MRP8/14. CONCLUSION: MRP8/14 is located in neutrophil cytosol and secondary granule fractions and is loosely associated with plasma membranes. MRP8/14 released with secondary granules by activated neutrophils likely binds to endothelium and plays an important role in acute inflammation

Analgorithmic Framework for Automatic Detection and Tracking Moving Point Targets in IR Image Sequences

Imaging sensors operating in infrared (IR) region of electromagnetic spectrum are gaining importance in airborne automatic target recognition (ATR) applications due to their passive nature of operation. IR imaging sensors exploit the unintended IR radiation emitted by the targets of interest for detection. The ATR systems based on the passive IR imaging sensors employ a set of signal processing algorithms for processing the image information in real-time. The real-time execution of signal processing algorithms provides the sufficient reaction time to the platform carrying ATR system to react upon the target of interest. These set of algorithms include detection, tracking, and classification of low-contrast, small sized-targets. Paper explained a signal processing framework developed to detect and track moving point targets from the acquired IR image sequences in real-time.Defence Science Journal, Vol. 65, No. 3, May 2015, pp.208-213, DOI: http://dx.doi.org/10.14429/dsj.65.816

High-Responsivity Mid-Infrared Graphene Detectors with Antenna-Enhanced Photocarrier Generation and Collection

Graphene is an attractive photoconductive material for optical detection due to its broad absorption spectrum and ultrashort response time. However, it remains a great challenge to achieve high responsivity in graphene detectors because of graphene’s weak optical absorption (only 2.3% in the monolayer graphene sheet) and short photocarrier lifetime (<1 ps). Here we show that metallic antenna structures can be designed to simultaneously improve both light absorption and photocarrier collection in graphene detectors. The coupled antennas concentrate free space light into the nanoscale deep-subwavelength antenna gaps, where the graphene light interaction is greatly enhanced as a result of the ultrahigh electric field intensity inside the gap. Meanwhile, the metallic antennas are designed to serve as electrodes that collect the generated photocarriers very efficiently. We also elucidate the mechanism of photoconductive gain in the graphene detectors and demonstrate mid-infrared (mid-IR) antenna-assisted graphene detectors at room temperature with more than 200 times enhancement of responsivity (∼0.4 V/W at λ0 = 4.45 μm) compared to devices without antennas (<2 mV/W).United States. Air Force Office of Scientific Research (Grant FA9550-12-1-0289)United States. Intelligence Advanced Research Projects Activity (Grant N66001-13-1-2007)United States. Intelligence Advanced Research Projects Activity (Grant N66001-13-1-3005

A study of thermally-induced optical bistability and the role of surface treatments in Si-based mid-infrared photonic crystal cavities

We report the observation of optical bistability in Si-based photonic crystal cavities operating around 4.5 \mum. Time domain measurements indicate that the source of this optical bistability is thermal, with a time constant on the order of 5 \mus. Quality (Q) factor improvement is shown by the use of surface treatments (wet processes and annealing), resulting in an increase of Q-factor from 11,500 to 29,300 at 4.48 \mum. After annealing in a N2 environment, optical bistability is no longer seen in our cavities

Monolithic integrated-optic TDLAS sensors

ABSTRACT We are developing prototype chip-scale low-power integrated-optic gas-phase chemical sensors based on infrared Tunable Diode Laser Absorption Spectroscopy (TDLAS). TDLAS is able to sense many gas phase chemicals with high sensitivity and selectivity. Using semiconductor fabrication and assembly techniques, the low-cost integrated optic TDLAS technology will permit mass production of sensors that have wide ranging industrial, medical, environmental, and consumer applications. Novel gas sensing elements using low-loss resonant photonic crystal cavities or waveguides will permit monolithic integration of a laser source, sampling elements, and detector on a semiconductor materials system substrate. Practical challenges to fabricating these devices include: a) selecting and designing the high-Q microresonator sensing element appropriate for the selected analyte; and b) device thermal management, especially stabilizing laser temperature with the precision needed for sensitive spectroscopic detection. In this paper, we analyze the expected sensitivity of micro-resonator-based structures for chemical sensing, and demonstrate a novel approach for exploiting laser waste heat to stabilize the laser temperature

Excitability and Synaptic Alterations in the Cerebellum of APP/PS1 Mice

In Alzheimer's disease (AD), the severity of cognitive symptoms is better correlated with the levels of soluble amyloid-beta (Aβ) rather than with the deposition of fibrillar Aβ in amyloid plaques. In APP/PS1 mice, a murine model of AD, at 8 months of age the cerebellum is devoid of fibrillar Aβ, but dosage of soluble Aβ1–42, the form which is more prone to aggregation, showed higher levels in this structure than in the forebrain. Aim of this study was to investigate the alterations of intrinsic membrane properties and of synaptic inputs in Purkinje cells (PCs) of the cerebellum, where only soluble Aβ is present. PCs were recorded by whole-cell patch-clamp in cerebellar slices from wild-type and APP/PS1 mice. In APP/PS1 PCs, evoked action potential discharge showed enhanced frequency adaptation and larger afterhyperpolarizations, indicating a reduction of the intrinsic membrane excitability. In the miniature GABAergic postsynaptic currents, the largest events were absent in APP/PS1 mice and the interspike intervals distribution was shifted to the left, but the mean amplitude and frequency were normal. The ryanodine-sensitive multivescicular release was not altered and the postsynaptic responsiveness to a GABAA agonist was intact. Climbing fiber postsynaptic currents were normal but their short-term plasticity was reduced in a time window of 100–800 ms. Parallel fiber postsynaptic currents and their short-term plasticity were normal. These results indicate that, in the cerebellar cortex, chronically elevated levels of soluble Aβ1–42 are associated with alterations of the intrinsic excitability of PCs and with alterations of the release of GABA from interneurons and of glutamate from climbing fibers, while the release of glutamate from parallel fibers and all postsynaptic mechanisms are preserved. Thus, soluble Aβ1–42 causes, in PCs, multiple functional alterations, including an impairment of intrinsic membrane properties and synapse-specific deficits, with differential consequences even in different subtypes of glutamatergic synapses

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial

Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Methods: We did an international, multicentre, randomised, placebo-controlled trial in 164 hospitals in 15 countries. Patients were enrolled if the responsible clinician was uncertain whether to use tranexamic acid, were aged above the minimum age considered an adult in their country (either aged 16 years and older or aged 18 years and older), and had significant (defined as at risk of bleeding to death) upper or lower gastrointestinal bleeding. Patients were randomly assigned by selection of a numbered treatment pack from a box containing eight packs that were identical apart from the pack number. Patients received either a loading dose of 1 g tranexamic acid, which was added to 100 mL infusion bag of 0·9% sodium chloride and infused by slow intravenous injection over 10 min, followed by a maintenance dose of 3 g tranexamic acid added to 1 L of any isotonic intravenous solution and infused at 125 mg/h for 24 h, or placebo (sodium chloride 0·9%). Patients, caregivers, and those assessing outcomes were masked to allocation. The primary outcome was death due to bleeding within 5 days of randomisation; analysis excluded patients who received neither dose of the allocated treatment and those for whom outcome data on death were unavailable. This trial was registered with Current Controlled Trials, ISRCTN11225767, and ClinicalTrials.gov, NCT01658124. Findings: Between July 4, 2013, and June 21, 2019, we randomly allocated 12 009 patients to receive tranexamic acid (5994, 49·9%) or matching placebo (6015, 50·1%), of whom 11 952 (99·5%) received the first dose of the allocated treatment. Death due to bleeding within 5 days of randomisation occurred in 222 (4%) of 5956 patients in the tranexamic acid group and in 226 (4%) of 5981 patients in the placebo group (risk ratio [RR] 0·99, 95% CI 0·82–1·18). Arterial thromboembolic events (myocardial infarction or stroke) were similar in the tranexamic acid group and placebo group (42 [0·7%] of 5952 vs 46 [0·8%] of 5977; 0·92; 0·60 to 1·39). Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98). Interpretation: We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding outside the context of a randomised trial